Kojima's juiciest comments concerned MGS4. "Until now," said Kojima, "we've released two entries of the MSX2 Metal Gear series, and three entries in the Metal Gear Solid series. Add to this Portable Ops, and you get a total of six titles. All mysteries will be cleared up in Metal Gear Solid 4."
Kojima was very clear about the finality of MGS4. Everything will be cleared up in MGS4 -- and Snake may even suffer the very fate that's hinted at in the new E3 trailer. Said Kojima, "We'll clear up all mysteries in 4 and, in the end, after this, will Snake die!?".